Maki gives her a Hannibal Lecture, telling her to stop pretending to feel love because she's incapable of it.

In #45, Mezool gets this, again but this time for real.

In the movie, when Nobunaga is just discovering there is pleasure in little things, he gets turned into an out of control greed by Maki, which results in him fighting Eiji.

All this combined with how brutally OOO (who was in Berserker mode at the time) destroyed him makes his death scene rather bittersweet. After OOO shatters three of his Cores, his reaction to it is made rather sad by his childish voice and his horrified tone. It's easy to imagine he might have turned out much differently had things been different. Lost Ankh was mentally a child and had pretty much been made a Tyke Bomb by Kazari and the other Greeed.

It's also possible to feel this way for Lost Ankh at his demise.

All this psychological stress while bearing the physical strain on his body exerted by a lot of foreign extra Medals in him. He finally snapped at this, going into an Unstoppable Rage. It gets worse in the Christmas party scene: You can see his face light up with joy when he thought he found Mezool, only to find Hina instead. Gamel scored a lot of extra points in #16 when he was shown wandering around frantically, looking for Mezool and muttering her name again and again like a lost child looking for his mother.

Alas, Poor Villain: A lot of viewers were saddened when Gamel and Mezool died The latter because of her strict but reasonable motherly control of the group, and the former for his childish behavior.

Kamen rider ooo crossover fanfiction